Abstract
International Journal of Advance Research in Multidisciplinary, 2024;2(2):163-165
Evaluation of synergistic effect of plant derivatives by In vitro anti-coagulant studies
Author : B Rajitha, Meraj Unnisa, K Kiran Kumar, K Thrilochana Devi and Hobibar Rahman
Abstract
The process by which clots develop inside the walls of injured blood arteries is known as hemostasis. We sought to assess the potential anticoagulant impact of methanolic extracts in this work in order to stop irregular bleeding and keep intravascular blood in a fluid state. We have chosen plant derivatives for our project dissertation work, specifically Trigonella foenum graecum, Zingiber officinale and Allium sativum were tested for In vitro prothrombin time (PT) test. The term prothrombin time refers to the amount of time needed for coagulation to occur. Prothrombin time typically ranges from 11 to 15 seconds. Each of these plant derivatives has been shown to have anticoagulant properties on its own. Now our study focuses on the synergistic effect of the mentioned plant derivatives through In vitro anticoagulant studies. First, a preliminary screening for phytochemicals will be carried out and then the suggested activity will be evaluated. The effects of an In vitro anticoagulant were investigated using plasma that was extracted from normal human blood samples by measuring PT.
Keywords
Synergistic effect, anticoagulant property, Prothrombin time, hemostasis and phytochemical screening
