INTERNATIONAL JOURNAL OF ADVANCE RESEARCH
IN MULTIDISCIPLINARY

The goal of this research was to find therapeutic plants that might fight against MDR bacteria by testing their phytochemical composition and antimicrobial activity. The study used aqueous and 80% methanolic extraction processes to get the phytochemical components of Rumex abyssinicus, Cucumis pustulatus, Discopodium penninervium, Lippia adoensis, Euphorbia depauperata, Cirsium englerianum, and Polysphaeria aethiopica. The hydroalcoholic extract demonstrated notable antibacterial efficacy against microorganisms that are resistant to many drugs, with MIC values between 1.0 and 128.0 μg/ml and IZ widths between 11 and 29 mm. When extracts from E. depauperata and C. englerianum were tested against MRSA and Streptococcus pyogenes, a wide IZ range of 26-29mm was observed. The IZ diameters of E. coli and multidrug-resistant Klebsiella pneumoniae were 12–25mm and 23–28mm, respectively. While all of the extracts tested were efficient against T. mentagraphytes, C. englerianum shown to be more beneficial against S. pyogenes and K. pneumoniae. Cirsium englerianum, L. adoensis, D. penninervium, and R. abyssinicus all shown antifungal activities against Candida albicans and Candida mentagrophytes. Among them, R. abyssinicus had the strongest antifungal action, with minimum inhibitory concentration (MIC) values ranging from 32 to 64 μg/ml. There is no difference between the antibacterial activity of the plant extracts and that of modern medications.