Abstract
International Journal of Advance Research in Multidisciplinary, 2024;2(2):317-323
The role of genetic variations in drug metabolism and their impact on therapeutic outcomes
Author : Jeetendra Kumar Prajapati and Aman Shukla
Abstract
Medication interactions have been the focus of most prominent pharmacogenomics studies used in the medical field. Its effects on therapy and medication discovery are substantial. For treatment to advance, pharmacogenomics must be widely used. The complex role that genes play in determining how the body responds to drugs is the primary area of study. New advances in clinical treatments have led to the discovery of novel biomarkers that may be used to categorise patients according to their likelihood of responding to a certain drug. The goal is to enhance personalised treatment by ensuring that the correct medication is administered at the correct time in the correct amount and that the correct prescriptions are given. Variation in drug response between individuals is caused by a myriad of factors, including genetics, the environment, and the patient themselves, all of which influence the pharmacokinetics and/or pharmacodynamics of drugs. Pharmacogenomics influences drug development, disease susceptibility, and treatment effectiveness. To provide the groundwork for future pharmacogenomics applications, methodologies, or tactics, this study aims to provide a review.
Keywords
Pharmacogenomics, genetic approach, drug therapy, drug development, personalized medicine/therapy, human diseases