The Indian Knowledge System (IKS) represents a vast repository of traditional wisdom that has significantly contributed to various scientific disciplines, including biological sciences. Rooted in ancient texts such as the Vedas, Ayurveda, and Siddha, IKS offers valuable insights into plant-based medicine, biodiversity conservation, sustainable agriculture, and ecological balance. Integrating IKS with modern biological studies can enhance research methodologies and promote sustainability. This paper explores the role of IKS in revitalizing and enriching biological sciences by bridging the gap between traditional knowledge and contemporary scientific advancements. By incorporating indigenous practices, modern biology can adopt a more comprehensive and sustainable approach to health, ecology, and biodiversity management.