The study used inter-regulatory measures to discover and define bottleneck hub miRs, which have the potential to be useful PD indicators. In addition, our investigation illuminated other common pathways linked to PD, including cardiovascular, cancer, and various signaling pathways. This provides strong evidence that PD is a complex illness involving multiple biological mechanisms that collaborate. In order to understand the recurring pattern of regulation peculiar to AD, several network motifs were examined, including Feed Forward Loops (FFLs), Feed Back Loops (FBLs), and Multiple Input Modules (MIMs). Additionally, the study examined this network motif's epigenetic regulation in connection to miR-related lncRNAs, histone modification pattern, and DNA islands inside the miR promoter region. The function of these authorities in Alzheimer's disease was further reinforced We have integrated network-based topological and epigenetic factors into one set of rules to predict epigenetic microRNAs that weren't previously associated with the disease, paving the way for system-level epigenetic investigations of AD. by the results of the tissue specificity study.